Iron regulatory element
In molecular biology, the iron response element or iron-responsive element (IRE) is a short conserved stem-loop which is bound by iron response proteins (IRPs, also named IRE-BP or IRBP). The IRE is found in UTRs (untranslated regions) of various mRNAs whose products are involved in iron metabolism. For … See more The two leading theories describe how iron probably interacts to impact posttranslational control of transcription. The classical theory suggests that IRPs, in the absence of iron, bind avidly to the mRNA IRE. When … See more Genes known to contain IREs include FTH1, FTL, TFRC, ALAS2, Sdhb, ACO2, Hao1, SLC11A2 (encoding DMT1), NDUFS1, SLC40A1 (encoding … See more • 5'UTR • IRP See more Many genes regulated by IREs have clear and direct roles in iron metabolism. Others show a less obvious connection. ACO2 encodes an … See more • Page for Iron response element - Model I at Rfam • Page for Iron response element - Model II at Rfam See more WebOct 25, 2024 · This regulation can occur at different levels, but the best-understood system is the iron-dependent binding of iron regulatory proteins (IRPs) IRP1 and IRP2 to stem-loop structures [iron-responsive elements (IREs)] in the untranslated regions (UTRs) of the messenger RNAs (mRNAs) encoding various iron-related proteins . When cellular iron ...
Iron regulatory element
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WebBackground and objective: Hereditary hyperferritinemia-cataract syndrome (HHCS) is an autosomal dominant disorder characterized by bilateral cataracts and increased serum and tissue L-ferritin, in the absence of iron overload. The deregulation of ferritin production is caused by heterogeneous mutations in the iron regulatory element (IRE) of L-ferritin that … WebIron regulatory elements (IREs) are a family of 28 nucleotide, non-coding elements which regulate the translation of ferritin mRNA (iron storage), erythroid delta-aminolevulinic …
WebMay 15, 1991 · The ferritin iron regulatory element (IRE), a conserved sequence of 28 nucleotides in a hairpin loop, is a conserved mRNA-specific translational regulatory element; flanking the IRE are regions of varying sequence, which form 9-17 base pairs close to the 5' cap. P-90 is a ferritin mRNA-specific translation regulatory protein purified from ... WebIron regulatory proteins (IRPs) are RNA-binding proteins that bind to iron regulatory elements (IREs). IREs are hairpin structures with loops consisting of CAGUGN sequences and are located at the 5′ untranslated region (UTR) and 3′ UTR for ferritin mRNA and transfer mRNA, respectively. Measurement of serum ferritin levels has diagnostic utility.
WebDec 1, 1998 · Iron Regulatory Proteins–Central Regulators of Iron Homeostasis. The mechanism by which IREs regulate mRNA utilization occurs due to interaction with IRP1 … WebMay 15, 2002 · IRE indicates iron responsive element. In nonvertebrate animals and plants, structural analysis and functional studies in many species have either failed to reveal structures compatible with posttranscriptional regulation by iron, or have revealed sequences that are not functional IRP binding sites.
WebAug 1, 2003 · Iron is an essential element for nearly all living organisms. 1 It is a key functional component of oxygen transporting and storage molecules (eg, hemoglobin and myoglobin) and of many enzymes that catalyze the redox reactions required for the generation of energy (eg, cytochromes), the production of various metabolic …
WebApr 28, 2011 · Ferroportin expression was shown to be regulated translationally by intracellular iron through the iron-responsive element/iron-regulatory protein system and transcriptionally by heme, and these responses allow macrophages to match their iron export capacity to the fluctuating iron and heme load caused by episodic … how many shipping containers sinkWebFeb 24, 2024 · Trichomonas vaginalis is one of the most common sexually transmitted parasites in humans. This protozoan has high iron requirements for growth, metabolism, and virulence. However, iron concentrations also differentially modulate T. vaginalis gene expression as in the genes encoding cysteine proteinases TvCP4 and TvCP12. Our goal … how many shipping containers fit on a bargeWebJul 18, 2006 · The influence of the base-paired flanking region on structure and function of the ferritin mRNA iron regulatory element. J. Mol. Biol. 231, 230–240 (1993). how many shipping containers fit on one shipWebIron regulatory proteins (IRPs) and iron regulatory element (IRE) systems are well known in the progression of neurodegenerative disorders by regulating iron related proteins. IRPs … how did john wilkes booth assassinate lincolnWebAug 30, 2024 · Iron responsive elements (IREs) are mRNA stem-loop targets for translational control by the two iron regulatory proteins IRP1 and IRP2. They are found in the … how did john wick become a assassinWebIron regulatory elements (IREs) constitute a family of 28-nucleotide, non-coding, stem-loop structures that regulate iron storage, heme synthesis and iron uptake. They also participate in ribosome binding and control the mRNA turnover (degradation). how many shipping trucks are active in the usWebOct 1, 1999 · Introduction. Iron is an essential nutrient and a potential toxin. The cloning of the iron-regulatory proteins (IRPs) and understanding of their interaction with iron … how many shipping lines does cma cgm own