WebGENERAL PRINCIPLES 1 Drugs and the medicinal chemist 2 The why and the wherefore 3 Protein structure 4 Drug action at enzymes 5 Drug action at receptors 6 Receptor 7 Nucleic acids 8 Drug discovery and drug development 9 Drug design - drug/target interactions 10 Pharmacokinetics 11 Quantitative structure-activity relationships (QSAR) Weballowing it to form a covalent bond to the allosteric binding site, the inhibition is irreversible. The drug 6-mercaptopurine (Fig. 7.5), used in the treatment of leukaemia, is an example of an allosteric inhibitor. It inhibits the first enzyme involved in the syn-thesis of purines (section 6.1.1) and blocks purine syn-thesis.In turn, this blocks DNA synthesis. 7.3 Uncompetitive …

An Introduction To Medicinal Chemistry By Graham Patrick

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An Introduction to Medicinal Chemistry: …

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