WebSep 1, 2024 · Clonal hematopoiesis of indeterminate potential, or CHIP, is a common age-related condition, in which acquired mutations in hematopoietic stem cells lead to the … WebAug 13, 2024 · Age-related clonal hematopoiesis associated with adverse outcomes. ... (2024) Age-related diseases of inflammation in myelodysplastic syndrome and chronic myelomonocytic leukemia, Blood, …
Clonal hematopoiesis, aging, and cardiovascular diseases
WebAug 17, 2024 · The ageing process is associated with somatic mutations in haematopoietic stem cells, which can lead to clonal haematopoiesis. Recently, clonal haematopoiesis has emerged as a risk factor for cardiovascular disease, and the underlying mechanisms likely involve heightened inflammatory responses in leukocytes derived from mutated clones. WebMar 20, 2024 · Clonal haematopoiesis — the occurrence of somatic mutations and mosaic chromosomal alterations in blood cells — is associated with age-related diseases, autoimmunity, immunodeficiency and ... ta gra
Clonal haematopoiesis and dysregulation of the immune system
Web2 days ago · A study shows that clonal haematopoiesis of indeterminate potential is associated with an increased risk of chronic liver disease specifically through the promotion of liver inflammation and injury. WebOct 1, 2024 · The discovery of clonal hematopoiesis (CH) in older individuals has changed the way hematologists and stem cell biologists view aging. Somatic mutations accumulate in stem cells over time. While most mutations have no impact, some result in subtle functional differences that ultimately manifest in d … WebNov 10, 2024 · Cardiovascular and oncological diseases represent the global major causes of death. For both, a novel and far-reaching risk factor has been identified: clonal hematopoiesis (CH). CH is defined as clonal expansion of peripheral blood cells on the basis of somatic mutations, without overt hematological malignancy. The most commonly … basis cpd organiser