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WebHow to Take Metformin. It is really important to start on a low dose of usually 500mg once a day with food, increasing after 2 weeks to either twice daily or at an increased daily dose with your evening meal. You will then increase doses at these time-points as instructed by your doctor depending on the effects on your blood sugars. WebOct 12, 2016 · Metformin brings down blood sugar by making insulin work better (decreasing insulin resistance) and causing the liver to make less sugar. It can take several days or even weeks before metformin works well. What if I miss a dose? Take your dose as soon as you remember. If it is more than 2 hours from your missed dose, then skip … WebJan 6, 2024 · It also makes your body respond better to insulin. Insulin is the hormone that controls the level of sugar in your blood. It's best to take metformin with a meal to reduce the side effects. The most common side effects are feeling sick, vomiting, diarrhoea, stomach ache and going off your food. dewalt dw056 18v cordless impact driver